For many individuals, certain medications are crucial for managing specific conditions and helping them live full and vibrant lives. Two of these commonly used medications include Wellbutrin and Adderall.
Wellbutrin, also known by its generic name bupropion, is primarily used as an antidepressant and smoking cessation aid. It works by altering the balance of certain neurotransmitters in the brain, particularly norepinephrine and dopamine.
On the other hand, Adderall is a stimulant medication commonly prescribed for ADHD and narcolepsy. It, too, affects neurotransmitter levels, leading to increased focus and reduced impulsivity.
While it might sound like these two medications would work well together, a Wellbutrin and Adderall combination can have risky effects. Below, we take a closer look at the dangers of combining Wellbutrin and Adderall and everything else you should know.
Medical Uses of Wellbutrin and Adderall
As previously mentioned above, Wellbutrin is most frequently used as an antidepressant, such as for major depressive disorder and seasonal affective disorder, and as a smoking cessation aid. It works by restoring the balance of dopamine and norepinephrine in the brain, leading to a stable mood.
In contrast, Adderall is used in the management of Attention Deficit Hyperactivity Disorder (ADHD). It also changes certain substances within the brain, increasing the ability to pay attention and focus.
Technically, Adderall is a stimulant. This means it’s also used for treating some sleeping disorders; it’s given to help an individual stay awake during the day but isn’t recommended to take later in the day due to its interference with sleep.
Why Combining Wellbutrin and Adderall is Risky
While both have their uses and can have the properties you need, there are dangers of combining Wellbutrin and Adderall. The main risks include:
1. Neurotransmitter Overload
The major problem with taking both of these medications is that each increases dopamine and norepinephrine. When combined, this leads to an overstimulation of the nervous system due to these increased neurotransmitter levels.
In rare and severe cases, serotonin syndrome may occur. This is a serious drug reaction that is caused by an excess serotonin in one’s system.
2. Increased Risk of Seizures
Wellbutrin, especially in higher doses, already has a risk of seizures. Meanwhile, Adderall can lower the threshold at which seizures may occur. This can be especially concerning for those with an already high seizure risk or for those who are prone to seizures. And this is another reason why combining these two medications isn’t often advised.
3. Increased Cardiovascular Risks
Both of these medications can increase heart rate and blood pressure. As a result, this could lead to high blood pressure and an abnormally fast heart rate. These risks may further be more profound in individuals with an already increased risk of cardiovascular issues.
4. Psychological Effects
Adderall and Wellbutrin side effects both include increased anxiety and paranoia. Thus, combined, these effects could be more significant, leading to serious psychological harm.
Side Effects of Combining Wellbutrin and Adderall
If you notice any side effects of these drugs individually or combined, it’s crucial to seek out medical attention.
Wellbutrin side effects may include:
- Chills
- Anxiety
- Body aches
- Cough
- Dry mouth
- Difficulty sleeping
- Irritability
- Irregular heartbeat
- Hyperventilation
- Shaking
- Sneezing
- Sore throat
- Runny nose
Adderall side effects may include:
- Weight loss
- Loss of appetite
- Stomach pain
- Dry mouth
- Nausea
- Dizziness
- Diarrhea
- Headaches
- Fever
- Trouble sleeping
- Anxiety or increased nerves
- Difficulty sleeping
Combined, these two drugs may lead to:
- Panic attacks
- Increased sleep disturbances/insomnia
- Increased agitation
- Severe mood swings
- Paranoia
- Hallucinations
- Seizures
- Muscle tremors
- Excessive sweating
- Confusion
As with many drugs, there is also a potential for dependency. For instance, abruptly discontinuing the use of either drug may cause intense fatigue, depression, vivid dreams, and sleep issues.
The Risk of Addiction and Misuse
Your doctor should communicate any and all Wellbutrin and Adderall interactions with you before you begin taking either drug. This is especially important due to their stimulant effects.
In fact, Adderall is a Schedule II controlled substance due to its high potential for abuse and dependence. Its psychological effects, including increased energy and a feeling of euphoria, often can lead to abuse and misuse.
As discussed above, Wellbutrin can amplify the effects of Adderall. In turn, this can increase the dependency or abuse of both of these substances. Additionally, tolerance can develop with either drug, which may lead to higher dosages. At higher dosages, health risks and dependency issues further increase.
This indicates the importance of using these medications only with a prescription and proper medical supervision. This ensures your health and safety are put first every step of the way.
Conclusion
The combination of Wellbutrin and Adderall carries significant risks that must be thoroughly understood and considered, as per the above. Thus, it’s critical to consult with a healthcare professional before combining these two medications. A healthcare professional can guide you on the best approach to your health and the safe way to manage any conditions you might be facing.
References
- https://www.webmd.com/drugs/2/drug-13509/wellbutrin-oral/details
- https://www.webmd.com/drugs/2/drug-63163/adderall-oral/details
- https://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/symptoms-causes/syc-20354758
- https://pubmed.ncbi.nlm.nih.gov/2500425/
- https://www.medicalnewstoday.com/articles/325188
- https://www.mayoclinic.org/drugs-supplements/bupropion-oral-route/side-effects/drg-20062478
- https://www.webmd.com/drugs/2/drug-63163/adderall-oral/details
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/011522s040lbl.pdf
